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. 2019 Apr 29;8(8):785–796. doi: 10.1002/sctm.18-0260

Figure 5.

Figure 5

Cryopreserved adipose‐derived mesenchymal stem cells (ASCs) treatment was associated with a profound transcriptomic response in the lungs of infected mice. (A): Principal component plot of highly expressed transcripts (n = 10.218) grouped as control (vehicle) or Cry‐ASCs (treated with cryopreserved adipose‐derived stem cells) mice infected with Klebsiella pneumoniae. (B): Volcano plots (integrating adjusted p‐values and fold expression [log2 fold change]) depicting the global alteration in gene expression after treatment with cryopreserved ASCs relative to infected controls. Horizontal line indicates Benjamini–Hochberg (BH) adjusted p < .05. Red dots denote overexpressed genes; turquoise dots indicate underexpressed genes. (C): Ingenuity pathway analysis of elevated transcripts (red bars) and reduced transcripts (turquoise bars) with BH adjusted Fisher's p < .01 demarcating significance. (D): Heatmap representation of transcript expression (rows) grouped as Ingenuity canonical signaling pathways in control and Cryo‐ASC treated animals infected with K. pneumoniae. Red, high expression; turquoise, low expression.