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. 2019 Jun 7;17:455–464. doi: 10.1016/j.omtn.2019.04.030

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Inhibition of SPRY4-IT1 Promotes G1 Arrest, Migration and Invasion, and Causes Apoptosis in GC Cells In Vitro

(A) The flow cytometry assay showed that BGC823 cells transfected with si-SPRY4-IT1 had cell-cycle arrest at the G1-G0 phase in comparison with control cells. (B) The flow cytometry assay showed that MKN28 cells transfected with pcDNA-SPRY4-IT1 had cell-cycle arrest at the S phase in comparison with control cells. (C) The flow cytometry assay showed that BGC823 cells transfected with si-SPRY4-IT1 had a higher apoptotic rate in comparison with control cells. (D) The flow cytometry assay showed that MKN28 cells transfected with pcDNA-SPRY4-IT1 had a lower apoptotic rate in comparison with control cells. (E) The migration of BGC823 cells was significantly inhibited by si-SPRY4-IT1, and the migration of MKN28 cells was markedly increased by pcDNA-SPRY4-IT1. (F) The invasion of BGC823 cells was significantly inhibited by si-SPRY4-IT1, and the invasion of MKN28 cells was markedly increased by pcDNA-SPRY4-IT1. All tests were performed at least three times. Data were expressed as mean ± SD. **p < 0.01.