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. 2019 Jun 7;17:455–464. doi: 10.1016/j.omtn.2019.04.030

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

SPRY4-IT1 Maintains Stem-like Phenotype in GC In Vitro

(A) Analysis of self-renewal of MKN28 cells with overexpression of SPRY4-IT1. (B) Flow cytometry analysis of ALDH1, CD73, and CD146 for MKN28 cells with overexpression of SPRY4-IT1 from generation G3 spheres. (C) Analysis of self-renewal of BGC823 cells with si-SPRY4-IT1. (D) Flow cytometry analysis of ALDH1, CD73, and CD146 for BGC823 cells with si-SPRY4-IT1 from generation G3 spheres. The data are presented as the means ± SD from three independent experiments. **p < 0.01, *p < 0.05.