Table 1.
Compound | K D (μM) | Soret peak shift (nm) | MIC (μg/mL) |
---|---|---|---|
10 a | 60.5±10.5 | 416.5 to 419 | 12.5 |
10 b | 53.6±6.8 | 416.5 to 421 | 12.5 |
10 c | 18.3±3.4 | 416.5 to 420 | 1.562 |
10 d | 53.7±5.9 | 416.5 to 420 | 0.781 |
10 e | 22.5±3.5 | 416.5 to 423 | 1.562 |
10 f | 0.22±0.01 | 416.5 to 423.5 | 1.562 |
10 g | 4.81±0.31 | 416.5 to 419.5 | 1.562 |
10 h | 2.91±0.14 | 416.5 to 423.5 | 3.125 |
10 i | 10.1±0.3 | 416.5 to 422.5 | 3.125 |
10 j | 3.31±0.05 | 416.5 to 423.5 | 25 |
11 a | 115.3±27.0 | 416.5 to 417.5 | >100 |
11 b | 249.7±51.6 | 416.5 to 417.5 | >100 |
13 a | 83.2±3.9 | 416.5 to 423.5 | 100 |
13 b | 85.6±12.4 | 416.5 to 417.5 | >100 |
14 a | 218.6±13.6 | 416.5 to 419.5 | >100 |
14b | 39.0±8.2 | 416.5 to 417.5 | >100 |
23 | 34.5±4.8 | 416.5 to 418 | >100 |
24 | 105±7 | 416.5 to 418 | >100 |
25 | 22.9±0.2 | 416.5 to 418.5 | 25 |
26 | 98.3±7.4 | 416.5 to 416 | 100 |
1 | 2.6±0.2 | 416.5 to 424 | 12.5 |
2 | 73.5±0.7 | 416.5 to 422.5 | 50 |
Fluconazole | 8.6±0.2 | >100 | |
Clotrimazole | 0.07±0.01 | 20 | |
cYY | 5.82±0.16 | – |