Table 6.
Reclassification of participants in the combined development and validation data sets using eGFRmet vs eGFRcr according to mGFR greater and lower than 60 mL/min/1.73 m2.
| Total group | Subgroup with mGFR <60 mL/min/1.73 m2 |
Subgroup with mGFR ≥60 mL/min/1.73 m2 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| eGFRcr range, mL/min/1.73 m2 |
n | Total reclassified n (%) |
n | Correctly reclassifieda n (%) |
Incorrectly reclassifiedb n (%) |
Net difference, % |
n | Correctly reclassifiedb n (%) |
Incorrectly reclassifieda n (%) |
Net difference, % |
Overall NRIc
(95% Cl) |
| Overall | 2424 | 349 (14.4) | 1,367 | 72 (5.3) | 72 (5.3) | 0 | 1057 | 132 (12.5) | 73 (6.9) | 5.6 | 5.6 (2.4–8.7) |
| 30–89 | 1864 | 347 (18.6) | 942 | 72(7.6) | 72 (7.6) | 0 | 922 | 132 (14.3) | 71 (7.7) | 6.6 | 6.6 (2.7–10.5) |
| 45–74 | 1123 | 322 (28.7) | 495 | 68(13.7) | 68 (13.7) | 0 | 628 | 127 (20.2) | 59 (9.4) | 10.8 | 10.8 (4.5–17.1) |
| 60–74 | 546 | 127 (23.3) | 118 | 68(57.6) | NAd | NA | 428 | NA | 59 (13.8) | NA | NA |
| 45–59 | 577 | 195 (33.8) | 377 | NA | 68 (18.0) | NA | 200 | 127 (63.5) | NA | NA | NA |
a
eGFRcr ≥ 60 and eGFRmet < 60.
b
eGFRcr < 60 and eGFRmet ≥ 60.
c
Values for NRI can be from −200 to 200. P < 0.001 for all.
d
NA, not applicable; NRI, net reclassification index.