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Permeability (P s) for Gadomer‐17 in wild‐type (wt) mice and Epac1−/− mice in control (i.v. saline) and after histamine administration determined with the two compartment model and the slope/step method. **P < 0.01 for histamine vs control and ##P < 0.01 and ###P < 0.001 for the same situation comparing within wt and Epac1−/−
