Table 1.
The table summarizes relevant data relative to experimental Alzheimer’s disease (AD) models for which hippocampal electrophysiological analyses were performed.
| Categories | Models | Species | Electrophysiological alteration | References | ||||
|---|---|---|---|---|---|---|---|---|
| BST | PPF | LTP | LTD | |||||
| In vitro models | Soluble Aβ oligomers treatment of hippocampal slices | Rat | – | – | ↓ CA1 | – | Lambert et al. (1998) | |
| Rat | NC | ↓ DG | NC | Wang et al. (2002) | ||||
| Mouse | NC | NC | ↓ CA1 | ↑ CA1 | Shankar et al. (2008) | |||
| APP over-expression in organotypic slices | Rat | ↓ | NC | ↓ CA1 | – | Kamenetz et al. (2003) | ||
| Transgenic animal models | APP-derived models | APP (K670N/M671L) (APP23) | Mouse | ↓ | NC | NC | – | Roder et al. (2003) |
| APP (K670N/M671L) (Tg2576) | Mouse | NC | NC | ↓ CA1 | – | Chapman et al. (1999) | ||
| ↓ DG | ||||||||
| Mouse | NC | NC | NC | ↑ CA1 | D’Amelio et al. (2011) | |||
| APP (V717F) (APPind) | Mouse | ↓ | NC | NC | – | Hsia et al. (1999) | ||
| APP (K670N/M671L)/APP (V717F)(J20) | Mouse | NC | NC | ↓ CA1 | NC | Nalbantoglu et al. (1997) | ||
| Mouse | NC | ↓ | ↓ DG | – | Palop et al. (2007) | |||
| APP (K670N/M671L)/PS1 (P264L) (Tg2576/PS1) | Mouse | NC | NC | ↓ CA1 | ↑ CA1 | Lanté et al. (2015) | ||
| PS1-derived models | PS1 (M146L) | Mouse | – | – | ↑ CA1 | – | Barrow et al. (2000) | |
| PS1 (WT)/PS1 (A246E) | Mouse | NC | NC | ↑ CA1 | – | Parent et al. (1999) | ||
| PS1(A246E) | Mouse | – | NC | NC-CA1 | – | Schneider et al. (2001) | ||
| PS1 (L286V) | Mouse | NC | NC | ↓ CA1 | – | Auffret et al. (2009) | ||
| APP/PS models | APP (K670N/M671L)/PS1 (M146L) | Mouse | ↓ | NC | ↓ CA1 | Trinchese et al. (2004) | ||
| APP (KM670/671NL)/PS1 (L166P) | Mouse | NC | – | ↓ CA1 | Calella et al. (2010) | |||
| APP (K670N/M671L)/PS1 (P264L)(Tg2576/PS1) | Mouse | NC | NC | ↓ CA1 | ↑ CA1 | Chang et al., (2006) | ||
| APP (K670N/M671L)/PS1 (M146V) | Mouse | NC | – | ↓ CA1 | ↓ CA1 | Song et al. (2014) | ||
| APP (K670N/M671L)/PS2 (N141I) | Mouse | NC | NC | ↓ CA1 | – | Richards et al.(2003) | ||
| ↑ | ↓ | ↓ DG | – | |||||
| 3xTg model | APP (K670N/M671L)/MAPT (P301L)/PS1 (M146V) | Mouse | ↓ | NC | ↓ CA1 | – | Oddo et al. (2003) | |
| 5xFAD model | APP (K670N/M671L) /APP (I716V) /APP (V717I)/PS1 (M146L; L286V) | Mouse | ↓ | NC | ↓ CA1 | – | Kimura et al. (2009) | |
Models were grouped into in vitro models, APP-derived, PS1-derived, APP/PS1, 3xTg, and 5xTg models. Electrophysiological readouts include basal synaptic transmission (BST), paired pulse facilitation (PPF), long-term potentiation (LTP), and long-term depression (LTD). For each model, we also report the principal references to the electrophysiological studies.