Table 1. Adverse Markers for Progression.
| Variablea | Adverse Marker | Points |
|---|---|---|
| MGUS | ||
| M spike isotype | IgA | 1 |
| M spike concentration | ≥15 g/L | 1 |
| Serum FLC ratio (κ:λ) | <0.1 or >10 | 1 |
| Immunoparesis | Uninvolved immunoglobulins below lower level of normal | 1 or 2 |
| Light-Chain MGUS | ||
| Serum FLC ratio (κ:λ) | <0.1 or >10 | 1 |
| Immunoparesis | Uninvolved immunoglobulins below lower level of normal | 1, 2, or 3 |
Abbreviations: FLC, serum free light chain; M spike, monoclonal spike; MGUS, monoclonal gammopathy of undetermined significance.
a
MGUS risk category for progression to multiple myeloma: 0 to 1, low-risk and low-risk light chain; 2, intermediate-risk and intermediate-risk light chain; 3 or higher, high-risk and high-risk light chain.