Table 1. Outcomes and Characteristics of the Analytic Sample.
Outcome | Countries | Total | ||||
---|---|---|---|---|---|---|
Denmark | Finland | Sweden | Israel | Western Australia | ||
Families, No.a | 183 034 | 160 570 | 262 047 | 37 430 | 37 421 | 680 502 |
Children, No.b | 528 052 | 472 959 | 753 125 | 131 147 | 116 348 | 2 001 631 |
Sex, No. | ||||||
Male | 270 844 | 241 909 | 388 126 | 67 237 | 59 430 | 1 027 546 |
Birth cohort | ||||||
1998-2002 | 270 564 | 240 984 | 360 351 | 75 220c | 57 822 | 974 085 |
2003-2007 | 257 488 | 231 975 | 392 774 | 55 927d | 58 526 | 929 721 |
ASD cases, No. | 7580 | 2968 | 10 563 | 490 | 555 | 22 156 |
AD cases, No. | 2676 | 709 | 4303 | NA | 459 | 8147 |
Asperger syndrome, No. | 1731 | 1044 | 3557 | NA | 7 | 6339 |
PDD-NOS | 3173 | 1215 | 2703 | NA | 89 | 7180 |
Children, No. | ||||||
Cousinse | 467 836 | 404 410 | 652 803 | 113 851 | 109 550 | 1 748 450 |
mPCsf | 119 257 | 104 218 | 168 524 | 25 052 | 28 899 | 445 950 |
Full siblingsg | 355 099 | 330 948 | 518 762 | 106 893 | 80 394 | 1 392 096 |
ASD concordance pairs, No. | ||||||
Cousins | 99 | 10 | 121 | 4 | 2 | 236 |
mPCs | 30 | 3 | 33 | 3 | 1 | 70 |
Full siblings | 191 | 69 | 353 | 7 | 19 | 639 |
Abbreviations: AD, autistic disorder; ASD, autism spectrum disorder; mPCs, maternal parallel cousins; NA, not available; PDD-NOS, pervasive developmental disorder not otherwise specified.
Data were organized in unit of family based on relatedness type in the Methods section.
Owing to data structure requirement by the statistical modeling, replicates exist (eAppendix 2: Analytic Sample Ascertainment in the Supplement).
Birth cohort 2000-2005.
Birth cohort 2006-2011.
Cousins are defined as children (cousins and full siblings) in the paired cousin families.
mPCs is defined as children (cousins and full siblings) in the families based on maternal parallel cousin pairs.
Full siblings are defined as full siblings from all 4 types of families defined based on relatedness.