. 2019 Jul 22;76(10):1192–1202. doi: 10.1001/jamaneurol.2019.2099

Table 2. Association Between Discharge Oral Anticoagulants and Clinical Outcomes.

Outcomes	Events, No. (Events per 100 Patient-Years, No.)				P Value
Outcomes	Direct Oral Anticoagulants (n = 4041)	Warfarin (n = 7621)	Unadjusted Hazard Ratio (95% CI)	Adjusted Hazard Ratio (95% CI)	P Value
Primary Outcomes
Home time during the first year postdischarge, d
Median (IQR)	348 (259-365)	331 (201-360)	27.5 (20.5-34.6)^a	15.6 (9.0-22.1)^a	<.001
Mean (SD)	287.2 (114.7)	263.0 (127.3)	27.5 (20.5-34.6)^a	15.6 (9.0-22.1)^a	<.001
Major adverse cardiovascular events	1930 (34.0)	4476 (40.4)	0.82 (0.76-0.87)^b	0.89 (0.83-0.96)^b	<.001
Secondary Outcomes^c
Mortality
All-cause	1183 (15.8)	3028 (19.6)	0.78 (0.73-0.84)	0.88 (0.82-0.95)	<.001
Fatal bleeding^d	59 (0.8)	164 (1.1)	0.71 (0.53-0.93)	0.84 (0.63-1.12)	.23
Readmission
All-cause	2353 (53.1)	5052 (62.4)	0.84 (0.80-0.88)	0.93 (0.88-0.97)	.003
Cardiovascular	1267 (22.3)	2770 (25.0)	0.86 (0.81-0.92)	0.92 (0.86-0.99)	.02
Ischemic stroke	380 (5.6)	770 (5.6)	0.97 (0.86-1.09)	1.01 (0.89-1.14)	.91
Systemic embolism	42 (0.6)	100 (0.7)	0.84 (0.58-1.21)	0.95 (0.66-1.38)	.80
Hemorrhagic stroke	54 (0.8)	151 (1.0)	0.69 (0.51-0.93)	0.69 (0.50-0.95)	.02
Gastrointestinal bleeding	367 (5.4)	714 (5.1)	1.01 (0.90-1.15)	1.14 (1.01-1.30)	.03
Any bleeding^e	728 (11.4)	1717 (13.4)	0.82 (0.75-0.89)	0.89 (0.81-0.97)	.009
Negative outcome control
Pneumonia^f	546 (8.1)	1256 (9.2)	0.85 (0.77-0.93)	0.96 (0.87-1.06)	.40
Sepsis^f	481 (7.0)	1151 (8.3)	0.81 (0.73-0.90)	0.95 (0.85-1.06)	.37

Abbreviation: IQR, interquartile range.

^{^a}

Differences with 99% CIs; all other values are reported as hazard ratios.

^{^b}

Hazard ratios with 99% CIs (all secondary outcomes are reported with 95% CIs).

^{^c}

All secondary outcomes are reported as hazard ratios with 95% CIs.

^{^d}

Rehospitalization for bleeding with in-hospital mortality.

^{^e}

Rehospitalization for bleeding.

^{^f}

Either primary or secondary diagnoses.