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. 2019 Jul 16;12:5729–5739. doi: 10.2147/OTT.S206932

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© 2019 Tu et al.

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miR-34c negatively regulated HMGB1 expression in non-small cell lung cancer cells by directly binding to HMGB1. (A) The putative binding sites between the 3ʹ-UTR of HMGB1 and miR-34c. (B) Interaction between HMGB1 and miR-34c was verified by the dual-luciferase reporter assay. (C) The levels of HMGB1 expression in A549 and NCI-H157 cells transfected with miR-34c, the NC or mimics were measured by Western blot assays.