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. 2019 Jul 18;14:5449–5475. doi: 10.2147/IJN.S213883

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© 2019 Jee et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Histological analysis during wound closure. The Carbopol hydrogel containing LMWP-GFs, QCN-NE, and OXY-PFOB-NE enhanced re-epithelialization and granulation tissue-formation in full-thickness skin wounds of diabetic mice within 12 days. Representative light micrograph images of sections from the wounds stained with (A) H&E to assess re-epithelialization, (B) CK6 (brown) as a marker for activated keratinocytes around the wound edge, (C) α-SMA (brown) to identify differentiated myofibroblasts in the wound, and (D) MT (blue) to identify collagen fibers in the wound at 3, 6, 9, and 12 days after treatment.

Notes: The scale bar equals 50 µm.

Abbreviations: LMWP, low-molecular-weight protamine; GFs, growth factors; LMWP-GFs, LMWP-fused GFs; QCN, quercetin; NE, nanoemulsion; QCN-NE, QCN-loaded NE; PFOB, 1-bromoperfluorooctane; OXY-PFOB-NE, oxygen-carrying PFOB-loaded NE; H&E, hematoxylin & eosin; CK6, cytokeratin 6; α-SMA, α-smooth muscle actin; MT; Masson’s trichrome.