Table 1:
Features predictive of disease progression in SSc-ILD.
| FEATURE | Reference |
|---|---|
| DEMOGRAPHIC | |
| Male gender | 60 |
| African-American race | 61 |
| DISEASE STATUS | |
| Diffuse cutaneous systemic sclerosis | 33 |
| BIOMARKERS | |
| Anti-SCL 70 Ab | 33 |
| Nucleolar pattern on ANA (representing anti-Th/To, U3 RNP) | 62 |
| CCL-2 | 64 |
| CCL-18 | 64 |
| Interleukin-6 | 65 |
| C-reactive protein | 38 |
| CXCL-4 | 66 |
| KL-6 | 67 |
| Surfactant protein D | 68 |
| PULMONARY FUNCTION TESTING | |
| Baseline FVC <70% | 69 |
| Baseline DLco <55% | 33 |
| IMAGING | |
| HRCT fibrosis >20%-25% | 21,22 |
| HRCT total lung involvement >20% | 5, 21 |