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. 2019 Jul 22;11:106. doi: 10.1186/s13148-019-0704-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — DNA methylation and response to guadecitabine. a Unsupervised hierarchical clustering of 116 r/r AML patients based on 2774 hypervariable sites (standard deviation > 10%) divided the cases into three clusters which were normal-like, CIMP-like, and intermediate methylation. b Kaplan-Meier survival analysis of 116 cases based on the clusters derived in a. There was a trend for longer survival in the “normal-like” cluster, but this trend was not statistically significant (p = 0.21 by log-rank test)