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. 2019 Jul 22;17:81. doi: 10.1186/s12964-019-0396-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — High doses of TNTL possessed hypoglycemic effects. a. showed that TNTL treatment did not significantly change the body weight of hyperglycemic mice; b. showed that TNTL dose-dependently suppressed the increase of random blood glucose (RBG) by week; c. showed that TNTL dose-dependently reduced fasting blood glucose (FBG) after 4-week treatment; d. showed that medium and high doses of TNTL improved the glucose tolerance in hyperglycemic mice; e. showed that TNTL at medium and high doses can significantly reduce serum HbA1c levels. *p < 0.05, **p < 0.01, ***p < 0.001 when compared with model group