Fig. 2.

Non-hypoglycemic doses of TNTL improved retina condition in diabetic mice. a. showed the representative of retina vascular preparation from mice with various treatment; The block arrows showed the acellular capillaries; b. showed that low-to-high doses of TNTL could significantly reduce the number of acellular capillaries on the retina vascular; c. showed that low-to-high doses of TNTL could significantly reduce the ratio of endothelial cell/pericytes; d. showed that TNTL improved blood-retina barrier (BRB) integrity and reduced Evans blue dye leakage; e. showed that low-to-high doses of TNTL could restore the number of retinal ganglion cells. f. co-immunostaining of Tuj1 and RBPMS showed that retinal ganglion cells were recovered by TTNL at ganglion cell layer; g. showed that TNTL recovered the density of Tuj1/RBPMS-positive retina ganglion cell in the in whole mount retinas. *p < 0.05, **p < 0.01 when compared with model group