Fig. 7.

The effect of ethanol and nicotine on locomotion of WIN55,212-2-treated larvae. Administration of ethanol (1% v/v) and nicotine (10 μM) to WIN55,212-2-pre-treated (125 nM) larvae increases the locomotion in both the light and dark phases, indicating that the immobility induced by the Cnr1 agonist is not due to a physical limitation. Group sizes are reported in parentheses. Data shown are means ± SEM. Significant differences compared to the corresponding phase of the vehicle/vehicle or WIN55,212-2/vehicle-treated control group are indicated. *P ≤ 0.05; **P ≤ 0.01; ****P ≤ 0.0001