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. 2019 Jul 22;17:231. doi: 10.1186/s12967-019-1981-5

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Validation of pulmonary artery hypertension in hypoxia-treated rats. a, b Representative right ventricular pressure (RVSP) recorded from control and hypoxic rats. c Right ventricular mass index (RVMI) showed right ventricular hypertrophy, as indexed by the right ventricle/(left ventricle + ventricular septal) [RV/(LV + S)] mass ratio. d Comparison of the PAs from the hypoxic group and with those from the normoxic control group, as assessed by the hematoxylin–eosin staining of paraffin sections