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. 2019 Jul 22;17:231. doi: 10.1186/s12967-019-1981-5

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Different characteristics between the hypoxic group and the control group. a The pie chart shows the DEGs. b Gene expression heatmap of hypoxia versus control groups: unsupervised hierarchical clustering analysis of the significantly dysregulated genes. Red: upregulated genes; green: downregulated genes. c Volcano plots for the transcriptome comparisons between the hypoxic group and the control group (Fold change > 1.5 and p < 0.05). d The pie chart shows the DEPs. e Volcano plots for the proteome comparisons between the hypoxic group and the control group (Fold change > 1.25 and p < 0.05). f The pie chart shows the DMRs, including promoter, exon, intron, and intergenic regions. The pie chart shows the number and proportion of upregulated and downregulated