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. 2019 Jul 22;14:29. doi: 10.1186/s13024-019-0329-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Structure of a single layer within a mature αS fibril. Based on the CryoEM structure published by Li et al [26] displaying formation of the ‘Greek Key’ topology with rotational symmetry about the axis of the fibril. The early onset mutations (E46K, H50Q, G51D/E, A53T) are highlighted (pink) in addition to three key electrostatic interactions that are perturbed in early onset PD (K58-E61, E46-K80 and K45/H50-E57)