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. 2019 Mar 21;48(5):425–445. doi: 10.1007/s00249-019-01355-6

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Authentic CRAC channel hallmarks of STIM1/Orai1 currents. (A) Current/voltage (I/V) relationship with a reversal potential (V_rev) > 0. (B) FCDI in a Ca²⁺-containing, Ba²⁺-containing compared to a Na⁺-containing divalent-free solution. (C) Alterations of currents upon the switch from a Ca²⁺ containing to a Na⁺- or Cs⁺-containing divalent-free solution (ratio of I_DVF/I_Ca2+). (D) Effects of 75 µM 2-APB upon full activation of STIM1/Orai1 currents

Graphs adapted from (Derler et al. 2018)