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. 2019 Mar 21;48(5):425–445. doi: 10.1007/s00249-019-01355-6

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Isoform-specific differences in the CRAC channel hallmarks. (A) Sequence alignement of Orai1, Orai3 and Orai1 Q72R Orai3–L2 of the ETON and TM1 region. Red lines mark the parts of the ETON region required for maintenance of store-operated activation, FCDI and a ratio of I_DVF:I_Ca2+ > 1. (B–D) Comparison of the authentic CRAC channel hallmarks, V_rev, FCDI, ratio of I_DVF:I_Ca2+ and effects of 2-APB on Orai1, Orai2 and Orai3.

Graphs adapted from Derler et al. (2009b, 2013b), Fahrner et al. (2018a), Frischauf et al. (2009), and Lis et al. (2007)