Table 1.

List of Orai mutants differentiated by their activation properties

	Store operated	Gain of function	Loss of function	References
Orai1 wildtype	X
Orai1 L74I	X			Derler et al. (2016b)
Orai1 Y80S	X			Derler et al. (2016b)
Orai1 L74/W76E/R/S	X			Derler et al. (2013a)
Orai1 K85E			X	Lis et al. (2010)
Orai1 R91W			X	Feske et al. (2006)
Orai1 S97C	X			Garibaldi et al. (2017)
Orai1 G98C/D/P	X			Yamashita et al. (2017), Zhang et al. (2011)
Orai1 G98R			X	Lian et al. (2017)
Orai1 G98S		X		Bohm et al. (2017)
Orai1 F99C/G/M/S/T/Y/W		X		Yamashita et al. (2017)
Orai1 V102A/C/G/S/T		X		McNally et al. (2012)
Orai1 V102I/L/M/V	X			McNally et al. (2012)
Orai1 A103E			X	McCarl et al. (2009)
Orai1 E106Q			X	Vig et al. (2006)
Orai1 V107M	X			Bohm et al. (2017)
Orai1 H134S/A/C/T/V/Q/E/M		X		Frischauf et al. (2017), Yeung et al. (2018)
Orai1 H134K/W			X	Yeung et al. (2018)
Orai1 A137V		X		Frischauf et al. (2017)
Orai1 L138F		X		Endo et al. (2015)
Orai1 M139V		X		Frischauf et al. (2017)
Orai1 S141C		X		Yeung et al. (2018)
Orai1 S159L		X		Frischauf et al. (2017)
Orai1 L174D			X	Zhou et al. (2016)
Orai1 W176C		X		Srikanth et al. (2011)
Orai1 A177D		X		Frischauf et al. (2017)
Orai1 V181A			X	Derler et al. (2018)
Orai1 G183A			X	Srikanth et al. (2011)
Orai1 G183D			X	Frischauf et al. (2017)
Orai1 T184M	X			Bohm et al. (2017), Bulla (2018)
Orai1 L185A		X		Fahrner et al. (2018a)
Orai1 F187C		X		Yeung et al. (2018)
Orai1 E190C		X		Yeung et al. (2018)
Orai1 E190Q	X			Prakriya et al. (2006)
Orai1 L194P			X	Lian et al. (2017), McCarl et al. (2009)
Orai1 A235C		X		Yeung et al. (2018)
Orai1 S239C		X		Yeung et al. (2018)
Orai1 G247S		X		Frischauf et al. (2017)
Orai1 F250C		X		Yeung et al. (2018)
Orai1 P245L		X		Nesin et al. (2014)
Orai1 L273S			X	Muik et al. (2008)
Orai1 L273D			X	Li et al. (2011)
Orai1 L276D			X	Navarro-Borelly et al. (2008)