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editorial

. 2019 Jul 23;18:94. doi: 10.1186/s12933-019-0899-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The three concepts that must be fulfilled for the definition of a class effect. Similar chemical structure, similar mechanism of action, similar pharmacological effects at the level of target organs; to all that, it must be added the statistical significance of the effect in each trial