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editorial

. 2019 Jul 23;18:94. doi: 10.1186/s12933-019-0899-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Class effects for the cardiorenal outcomes of SGLT-2 inhibitors. A class effect is not evident for MACE (only three trials demonstrated a significant reduction of the MACE risk), but is evident for heart failure (reduced risk of hospitalization for heart failure) and DKD progression (reduced decline of eGFR, renal death, or requirement for renal replacement therapy). MACE, major cardiovascular events; DKD, diabetic kidney disease; EMP, EMPAREG-OUTCOME; CAN, CANVAS; DEC, DECLARE; CRE, CREDENCE