Fig. 1.

Downregulated NEAT1 in AD contributes to Aβ uptake and degradation. a NEAT1 analysis in the hippocampi of 3-month-old AD mice (n = 10), 6-month-old AD mice (n = 10), 10-month-old AD mice (n = 10) and 3-month-old wild-type mice (n = 22). p values were calculated using the nonparametric Kolmogorov–Smirnov test. b NEAT1 analysis in the hippocampi of different Braak stage AD patients and normal controls in the AD dataset (GSE48350). p values were calculated using the nonparametric Kolmogorov–Smirnov test. c, d After addition of Aβ (1–42) to the siNEAT1 and siCTRL cells for the indicated times, the relative Aβ (1–42) concentrations were analysed by ELISA in three independent experiments. The data are represented as the mean ± SD. *p < 0.001