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. 2019 Jul 22;17:79. doi: 10.1186/s12964-019-0397-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Characterization of functional enrichment of DEGs reside in the MSI-H subtypes. a, Venn diagram displaying the number of genes that overlapped within DEGs and DMSs identified in TCGA and GSE39582 datasets. b, GO enrichment of up-regulated DEGs found in MSI-H1. c, KEGG pathway enrichment of up-regulated DEGs found in MSI-H1. d, Coexpression regulatory network identified by WGCNA. Genes that were not coexpressed were assigned to the gray group. Each vertical line corresponds to a gene, and branches are expression modules of highly interconnected groups of genes. In total, seven modules ranging from 146 to 2,939 genes in size were identified in MSI-H2. The yellow module associated with the immune response was selected for visualization