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. 2019 Jul 23;12:358. doi: 10.1186/s13071-019-3615-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Venn diagram of 5-mC and 5-hmC genes in the promoter region. A total of 2680 genes had hypomethylation (5-mC-CvT), and 2752 genes had hypermethylation (5-mC-TvC). There were 182 upregulated 5-hmC genes (5-hmC-TvC) and 178 downregulated 5-hmC genes (5-hmC-CvT). A total of 111 genes underwent both 5-mC and 5-hmC changes by cross-alignment