Table 4.
Summary of long-term safety outcomes of early hydrocortisone
| Outcome | Hydrocortisone | Control | Number of trials | Risk ratio (95% CI) | p value | NNT (95% CI) | ||
|---|---|---|---|---|---|---|---|---|
| Events | Total | Events | Total | |||||
| All studies | ||||||||
| Death until last FU | 91 | 482 | 112 | 494 | 4 | 0.83 (0.65, 1.06) | 0.14 | |
| Survival without moderate-severe NDI | 281 | 443 | 256 | 455 | 4 | 1.13 (1.02, 1.26) | 0.02 | 14 (7.4, 129.4) |
| Any NDI at FU | 41 | 138 | 45 | 138 | 2 | 0.91 (0.64, 1.29) | 0.60 | |
| Severe NDI at FU | 19 | 217 | 26 | 207 | 2 | 0.70 (0.40, 1.22) | 0.20 | |
| Cerebral palsy (survivors and FU) | 34 | 374 | 31 | 359 | 5 | 1.06 (0.67, 1.67) | 0.81 | |
| BPD studies | ||||||||
| Death until last FU | 83 | 460 | 103 | 472 | 3 | 0.83 (0.64, 1.07) | 0.15 | |
| Survival without moderate-severe NDI | 271 | 422 | 245 | 434 | 3 | 1.14 (1.03, 1.27) | 0.02 | 13 (7.0, 81.1) |
| Any NDI at FU | 39 | 126 | 44 | 126 | 1 | 0.89 (0.62, 1.26) | 0.50 | |
| Severe NDI at FU | 19 | 217 | 26 | 207 | 2 | 0.70 (0.40, 1.22) | 0.20 | |
| Cerebral palsy (survivors and FU) | 32 | 362 | 30 | 347 | 4 | 1.03 (0.64, 1.64) | 0.91 | |
Results from Bonsante 2007 were reported in the paper by Peltoniemi 2009, Fitzhardinge reported severe NDI at 1-year of age, and Watterberg 2007 reported severe NDI)
FU follow-up