Table 1.
BP-3 permeability through the BBB. BP-3 (25 μM) has a good permeability coefficient through the BBB. Evaluation of the permeability properties was measured according to the Papp value. The concentration of BP-3 in the organic phase was evaluated by measuring the total ion current (TIC) for the molecular mass of BP-3 on a TQD Waters mass spectrometer with ESI+ ionization, coupled with an H-class UPLC. The number of replicates was 6
| Replicate | Papp (cm/min) | Papp (10–6) cm/s |
|---|---|---|
| 1 | 0.000588111 | 9.803137744 |
| 2 | 0.00052516 | 8.753816746 |
| 3 | 0.000544321 | 9.073217155 |
| 4 | 0.000814718 | 13.58043162 |
| 5 | 0.000557757 | 9.29717601 |
| 6 | 0.000600898 | 10.01629517 |
| Mean ± SE | 0.00061 ± 0.000043 | 10.10 ± 0.7238 |