Fig. 3.

mRNA regulation of fibrinolytic and inflammatory marker genes in PAI-1 and PAI-2-deficient mice after MCAO. a, b Comparing the expression of tPA and uPA in native wild-type animals compared to PAI-1 and PAI-2-deficient mice. PAI-1-deficient mice show significantly lower tPA and uPA expression levels compared to wild-type mice, whereas PAI-2-deficient mice demonstrate only significantly lower uPA levels in the brain. c, d Modulation of tPA and uPA was similar to the time course study and without differences between groups at 1 day past injury (1 dpi). e, f Inflammatory parameters were upregulated over time without differences between groups. Data are shown as mean ± SEM (n = 10 per group; native: n = 4). Descriptive p values are assigned as follows: ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 using the Kruskal-Wallis test; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 using Welch’s test