Fig. 4.

Reduced infarct volume in PAI-1-deficient mice. a The infarct volumes were reduced in PAI-1-deficient mice by 31% compared to wild-type mice 24 h after insult (PAI-1^−/− 35 ± 11% of contralateral hemisphere, ^*p < 0.05; PAI-1^+/+/PAI-2^+/+ 51 ± 10% of contralateral hemisphere). PAI-2 deficiency did not influence brain injury (48 ± 13% of contralateral hemisphere). b The PAI-1 plasma activity was undetectable in PAI-1-deficient mice but increased over time without differences between wild-type or PAI-2-deficient mice (PAI-1^+/+/PAI-2^+/+ 5-fold increase, ^##p < 0.01 vs. native; PAI-2^−/− 3.5-fold increase, ^#p < 0.05 vs. native). c The neurological severity score showed no differences between groups. Data are shown as mean ± SEM (n = 10 per group; native n = 4). Descriptive p values are assigned as follows: ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 using the Kruskal-Wallis test; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 using Welch’s test