Table 3.

Effects of 13 weeks PedPRM and placebo treatment on total SDQ and respective behavior scores in subpopulations of subjects with abnormal behavior scores at baseline

Subpopulation	Treatment	N	Total SDQ adjusted treatment means (SE) [95% CI] at 13 weeks	p value*	Respective behavior adjusted treatment means (SE) [95% CI] at 13 weeks	p value*
Abnormal SDQ score ≥ 20	PedPRM	32	− 1.24 (0.496) [− 2.22, − 0.25]	0.012	− 1.24 (0.496) [− 2.22, − 0.25]	0.012
	Placebo	22	− 0.12 (0.553) [− 1.21, 0.98)	ns	− 0.12 (0.553) [− 1.21, 0.98)
Abnormal-hyperactivity score ≥ 7	PedPRM	42	− 1.06 (0.428) [− 1.91, − 0.21]	0.013	− 0.69 (0.221) [− 1.13, − 0.26]	0.002
	Placebo	31	0.40 (0.487) [− 0.57, 1.37]	ns	− 0.20 (0.248) [− 0.69, 0.29]	ns
Abnormal conduct score ≥ 5	PedPRM	8	− 0.51 (1.026) [− 2.54, 1.53]	0.64	− 0.78 (0.355) [− 1.48, − 0.08]	0.028
	Placebo	7	1.47 (0.922) [− 0.36, 3.30]	ns	0.33 (0.314) [− 0.30, 0.95]	ns
Abnormal peer relationship score ≥ 6	PedPRM	20	− 1.03 (0.598) [− 2.22, 0.16]	0.079	− 0.50 (0.229) [− 0.96, − 0.04]	0.029
	Placebo	17	0.15 (0.706) [− 1.25, 1.55)	ns	− 0.20 (0.255) [− 0.71, 0.30]	ns
Abnormal emotional score ≥ 7	PedPRM	12	− 1.57 (0.803) [− 3.16, 0.03]	0.050	− 1.31 (0.449) [− 2.20, − 0.42]	0.004
	Placebo	12	0.19 (0.819) [− 1.43, 1.82]	ns	− 1.32 (0.460) [− 2.24, − 0.41]	0.003

*Paired T-test from the change from baseline

ns not significant