Table 3.
Univariate analysis examining ipsilateral local recurrence after breast conserving surgery in relation to radiotherapy, age, intrinsic subtypes, proliferation index, Nottingham Histologic Grade (NHG), CD163-expression in tumor cells, and macrophage infiltration in breast cancer
| No radiotherapy | Radiotherapy | |||||
|---|---|---|---|---|---|---|
| Local recurrence | Local recurrence | |||||
| No N (%) | Yes N (%) | P | No N (%) | Yes N (%) | P | |
| Age group | ||||||
| ≤ 40 | 2 (10) | 6 (26) | 1 (4) | 6 (37) | ||
| 41–50 | 1 (5) | 5 (22) | 6 (24) | 6 (38) | ||
| 51–60 | 6 (32) | 3 (13) | 7 (28) | 1 (6) | ||
| 61–70 | 4 (21) | 1 (4) | 8 (32) | 2 (13) | ||
| ≥ 70 | 6 (32) | 8 (35) | 0.11 | 3 (12) | 1 (6) | 0.024 |
| Intrinsic subtypes Ki-67 | ||||||
| Luminal A | 11 (69) | 12 (60) | 15 (65) | 5 (36) | ||
| Luminal B HER2pos | 1 (6) | 0 (0) | 2 (9) | 2 (14) | ||
| Luminal B HER2neg | 2 (12.5) | 3 (15) | 2 (9) | 7 (50) | ||
| Triple negative | 2 (12.5) | 5 (25) | 0.55 | 4 (17) | 0 (0) | 0.017 |
| Proliferation index | ||||||
| Ki-67 < 14% | 14 (78) | 15 (68) | 20 (83) | 6 (43) | ||
| Ki-67 ≥ 14% | 4 (22) | 7 (32) | 0.5 | 4 (17) | 8 (57) | 0.01 |
| Nottingham grading system | ||||||
| NHG1 | 4 (21) | 5 (22) | 8 (32) | 3 (19) | ||
| NHG2 | 9 (47) | 10 (43) | 12 (48) | 7 (44) | ||
| NHG3 | 6 (32) | 8 (35) | 1 | 5 (20) | 6 (37) | 0.5 |
| CD163 expression | ||||||
| Negative (< 15%) | 15 (79) | 16 (73) | 21 (84) | 3 (20) | ||
| Positive (≥ 15%) | 4 (21) | 6 (27) | 0.64 | 4 (16) | 3 (20) | 0.75 |
| Macrophage infiltration | ||||||
| Low | 11 (58) | 11 (50) | 12 (48) | 7 (47) | ||
| Moderate | 5 (26) | 8 (36) | 10 (40) | 5 (33) | ||
| High | 3 (16) | 3 (14) | 0.8 | 10 (3) | 3 (20) | 0.8 |