We find that challenges of using biomedical big data (BBD) for economic evaluations of precision medicine relate to data management, data quality and data analysis.

While data management challenges are primarily practical and may not be long-term obstacles if procedures for data sharing and access are improved, data quality and analysis challenges may require an evolution in economic evaluation methods.

Health economists who present work that uses BBD should document challenges and the solutions they have applied to the challenges to support future researcher endeavours.