Table 1.
Genetic overlap analyses between anorexia nervosa (AN) and seven subcortical brain volumes
| ROI | LDSC | GRSa | Sign testa | SECA | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Volume | h2 in % | 95% CI | rg | se | p(rg) | R2 | p(GRS) | p threshold (brain volume) | Estimateb | 95% CI | p(binomial) | p threshold (brain volume) | p(pleiotropy) | p(concordance) |
| Caudate | 25.65 | [17.61,33.69] | 0.14 | 0.11 | 0.19 | 9.55E-05 | 0.120 | 1E-04 | 0.513 | [0.49,0.535] | 0.268 | 1E-02 | 1.000 | 1.000 |
| Hippocampus | 14.86 | [6.61,23.11] | − 0.06 | 0.15 | 0.66 | 3.42E-04 | 0.013c | 1E-02 | 0.522 | [0.499,0.544] | 0.061 | 1E-02 | 1.000 | 0.138 |
| Nucleus accumbens | 8.93 | [0.76,17.1] | 0.14 | 0.19 | 0.45 | 1.43E-04 | 0.075 | 1E-03 | 0.450 | [0.384,0.518] | 0.159 | 1E-03 | 0.057 | 0.052 |
| Pallidum | 15.25 | [6.84,23.66] | 0.10 | 0.14 | 0.47 | 2.65E-04 | 0.025c | 1E-02 | 0.522 | [0.499,0.545] | 0.065 | 1E-02 | 1.000 | 0.311 |
| Putamen | 30.80 | [20.78,40.82] | 0.05 | 0.10 | 0.61 | 1.26E-04 | 0.089 | 1E-04 | 0.438 | [0.374,0.503] | 0.061 | 1E-03 | 0.153 | 0.170 |
| Thalamus | 13.74 | [5.78,21.7] | − 0.10 | 0.15 | 0.49 | 2.23E-04 | 0.036c | 5E-02 | 0.512 | [0.502,0.523] | 0.019d | 5E-02 | 0.160 | 0.009c,d |
| ICV | 17.96 | [8.59,27.33] | 0.23 | 0.14 | 0.10 | 3.28E-04 | 0.015c | 1E-03 | 0.560 | [0.495,0.623] | 0.072 | 1E-03 | 1.000 | 0.078 |
ROI, region of interest; ICV, intracranial volume; LDSC, LD score regression; GRS, genetic risk score; SECA, SNP effect concordance analysis; amygdala volume was omitted from the analyses because of low heritability; heritability estimates on the observed scale; rg = genetic correlation with AN; p(rg) = p value of the genetic correlation; se = standard error; CI = confidence interval; a tests were carried out on subsets of four different thresholds (1*10−4, 1*10−3, 1*10−2, 5*10−2) in the discovery dataset (i.e., ENIGMA subcortical brain volume), but only the strongest results are reported in the table. For detailed results, see Tables S3 and S4. b An estimate > 0.5 indicates a higher-than-chance proportion of SNPs with a risk effect on brain volume (BETA<0) and on AN (OR > 1); c nominally significant at p < 0.05; d trend significance after Bonferroni-correction for 7 tests (number of brain volumes)