Fig. 5.

Motor and cognitive impairment in double-transgenic mice. a Representative figure of the cat-walk analysis at 12 months of age. Hindlimb paw is in red and forelimb paw in green. Stride length is the distance between paw from the same limb and base of support is the distance between the two hindlimbs or the two forelimbs. b Forelimb base of support at 18 months of age. Number of mice per group in parentheses. c Forelimb stride length at 18 months of age. Results are similar in hindlimb analysis (see suppl Fig. 3). d Rotarod score from 5 months of age to 18 months of age. Results are shown in relative score as compared to best mice capacity. e Rotarod score from 33 weeks of age to 45 weeks of age for non-transgenic (NTG) and double transgenic (UBQ; TDP). These are the only time point with significant differences. f Passive avoidance test represented in time to go in the dark at the third day (testing day) at 5 months of age and at 7 months of age in (g). h Pole test analysis at 15 months of age. Time to descend the pole was measured in seconds