Fig. 10.

MRI-spin-lock imaging of tumor pH. Measured R_1ρ dispersion curves for Iohexol at several pH values but constant agent concentration (a) and calibration curve for the fitted s0 parameter as a function of pH (b). ΔR_1ρ difference map at 10 min after injection (c) and corresponding pH map from the tumor-bearing rat brain calculated as average of six ΔR_1ρ difference maps at different time points after iohexol i.v. injection (d). Adapted with permission from Magnetic Resonance in Medicine 2018, 79, 298–305