Fig. 2.

Home cage activity and edema after ICH. a Acetazolamide did not affect home cage movement. b ICH significantly increased brain water content within in the injured hemisphere, but there was no effect of acetazolamide. Measurements were made on 6-mm tissue blocks encompassing the hemorrhage in the injured hemisphere, an equivalent area in the contralateral hemisphere, and the entire cerebellum (see “Materials and Methods”). c Brain water content in the injured hemisphere was not correlated with mean or peak ICP (r = − 0.347 to − 0.248, P ≥ 0.173, see “Results”). AU arbitrary units (measured by changes in probe signal strength as animals move nearer or farther from the receiver [48]). ***P < 0.001