Table 2.

Model input parameters used in EAC’s update of the company’s economic model

Parameter	EAC point estimate	Source	EAC range and source
Incidence of pressure ulcer—standard care	3.8%	NHS safety thermometer data [48] for new pressure ulcers in ICU (average incidence between February 2017 and February 2018) adjusted to account for poor sensitivity [49], missed stage 1 pressure ulcers and only heel and sacrum ulcers [50]	DSA: Range 2.5–46%. Lowest and highest values reported in comparative studies identified in clinical review [23, 42] PSA: Beta distribution with an SE of 20%. Range 2.3–5.2%
Incidence of pressure ulcer—Mepilex Border dressings	1.9%	Combined standard care pressure ulcer incidence with pooled relative risk (0.51) calculated by EAC	DSA: Range 0.2–0.86. Confidence interval from meta-analysis conducted by EAC PSA: Lognormal distribution, varied between 0.2 and 0.86. Confidence interval calculated by EAC as part of clinical review
Cost of pressure ulcer treatment—standard care	£4823	Costs from Dealey 2012 [51]. Weighted by NHS safety thermometer data [48] which was adjusted for stage 1 pressure ulcers [50]	DSA: Range £1299–£15,097 based on cost of stage 1 and stage 4 pressure ulcer [51] PSA: Gamma distribution with an SE of 20%. Range £2932–£6714. Costs of pressure ulcer treatment for standard care and Mepilex Border dressings are varied together in the base case. A scenario was run to explore the impact of varying them independently
Cost of pressure ulcer treatment—Mepilex Border dressings	£4823	Costs from Dealey 2012 [51]. Weighted by NHS safety thermometer data [48] which was adjusted for stage 1 pressure ulcers [50]	DSA: Range £1299–£15,097 based on cost of stage 1 and stage 4 pressure ulcer [51] PSA: Gamma distribution with an SE of 20%. Range £2932–£6,714. Costs of pressure ulcer treatment for standard care and Mepilex Border dressings are varied together in the base case. A scenario was run to explore the impact of varying them independently
Total number of Mepilex Border Sacrum dressings per patient	4	[20]	DSA: Range 1.5–5 PSA: Varied as part of total dressing costs (£20–£88)
Total number of Mepilex Border Heel dressings per patient	6	Assumption based on [20] and [52]	DSA: Range 2–10 PSA: Varied as part of total dressing costs (mean £58, range: £20–£88)
Cost of nurse time per minute	£0.62	Band 5 nurse cost [53], validated by clinical experts	DSA: Range £0.42–£0.83 [53] PSA: Varied as part of total nursing costs per patient (mean £12, range: £2–£37)
Total number of minutes allowed for all dressing changes per patient	20 min	2 min per dressing change (10 dressings, 4 sacrum, 6 heel) [52] Validated by clinical experts	DSA: Range 5.25–45 based on ranges used for number of dressings required and varying minutes required per dressing change between 1.5 and 3 PSA: Varied as part of total nursing costs per patient (mean £12, range: £2–£37)
Cost of Mepilex Border Sacrum dressing	£4.63	Prices for each dressing size weighted by sales figures. Provided by Mölnlycke Health Care	DSA: Not varied PSA: Varied as part of total cost of dressings per patient
Cost of Mepilex Border Heel dressing	£6.50	Prices for each dressing size weighted by sales figures. Provided by Mölnlycke Health Care	DSA: Not varied PSA: Varied as part of total cost of dressings per patient

DSA deterministic sensitivity analysis, EAC external assessment centre, ICU intensive care unit, NHS National Health Service, PSA probabilistic sensitivity analysis, SE standard error