Table 1.

Comparison of the IC₅₀ Values and % Inhibition of PON1 Activity by Naringenin and 2‐HQ

	Serum PON1 IC50 (µM)			% Inhibition of serum PON1d
Name of compound	Paraoxona	Phenylacetateb	Purified PON1 IC50 (µM)c	Paraoxona	Phenylacetateb	% Inhibition of purified PON1d
Naringenin	37.9	34.6	10	25	32	50
2‐HQ	1.8	1.4	<1	89	92	94

2‐HQ, 2‐hydroxyquinoline.

^{a a}For the assay of paraoxonase activity.

^{b b}For the assay of arylesterase activity.

^{c c}IC₅₀ values were determined by arylesterase activity.

^{d d}Naringenin and 2‐HQ were used at concentrations of 10 and 5 µM, respectively.