Table 3.
Risk of Coronary Heart Disease by AF Stratified by Age, Sex, and Race
| Subgroup | Events/No. at Risk | Model 1a, HR (95% CI) | P Value | Model 2b, HR (95% CI) | P Value | Interaction P Valuec |
|---|---|---|---|---|---|---|
| All | 1711/4608 | 2.0 (1.7‐2.3) | <0.0001 | 1.9 (1.6‐2.2) | <0.0001 | — |
| Age, years | ||||||
| ≤80 | 1537/4151 | 2.2 (1.9‐2.6) | <0.0001 | 2.1 (1.8‐2.5) | <0.0001 | |
| >80 | 174/457 | 1.6 (1.1‐2.5) | 0.020 | 1.6 (1.1‐2.4) | 0.028 | 0.088 |
| Sex | ||||||
| F | 898/2765 | 2.4 (2.0‐3.0) | <0.0001 | 2.3 (1.8‐2.8) | <0.0001 | |
| M | 813/1843 | 1.6 (1.3‐2.0) | <0.0001 | 1.6 (1.3‐2.0) | <0.0001 | 0.021 |
| Race | ||||||
| White | 1462/3911 | 1.9 (1.6‐2.2) | <0.0001 | 1.8 (1.6‐2.2) | <0.0001 | |
| Black | 249/697 | 2.8 (1.9‐4.2) | <0.0001 | 2.5 (1.7‐3.9) | <0.0001 | 0.27 |
Abbreviations: AF, atrial fibrillation; BMI, body mass index; CI, confidence interval; DM, diabetes mellitus; F, female; HDL‐C, high‐density lipoprotein cholesterol; HR, hazard ratio; hs‐CRP, high‐sensitivity C‐reactive protein; M, male; MI, myocardial infarction; SBP, systolic blood pressure.
a
Adjusted for age, sex, race, education, and income.
b
Adjusted for model 1 covariates plus smoking status, SBP, DM, BMI, total cholesterol, HDL‐C, aspirin, statins, antihypertensive medications, and log(hs‐CRP).
c
Interactions tested using model 2.