Table 2.
Comparison of Calculated Everolimus Concentration Obtained by Using Mathematical Equations With Everolimus Values Determined by Liquid Chromatography/Mass Spectrometry (LC/MS)
| Apparent Sirolimus (ng/mL) | Calculated Everolimus (ng/mL) | Everolimus | ||
|---|---|---|---|---|
| Specimen ♯ | Architect assay | Polynomial | Linear | (LC/MS) |
| 1 | 2.6 | 3.2 | 3.3 | 2.9 |
| 2 | 4.6 | 5.9 | 5.9 | 5.7 |
| 3 | 6.3 | 8.2 | 8.1 | 8.6 |
| 4 | 3.7 | 4.7 | 4.7 | 5.0 |
| 5 | 8.1 | 10.6 | 10.4 | 8.6 |
| 6 | 2.0 | 2.3 | 2.5 | 2.0 |
| 7 | 5.7 | 7.4 | 7.3 | 7.5 |
| 8 | 12.9 | 16.9 | 16.6 | 14.5 |
| 9 | 19.0 | 24.6 | 24.4 | 22.1 |
| 10 | 7.3 | 9.6 | 9.3 | 10.5 |
| 11 | 16.6 | 21.6 | 21.3 | 18.8 |
| 12 | 12.9 | 16.9 | 16.6 | 17.5 |