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. 2019 Mar 11;23(8):987–994. doi: 10.1007/s10157-019-01719-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — SIRT1-mediated deacetylation reaction. A variety of transcriptional factors and histones are deacetylated by SIRT1. There are two possibilities for the effects of the deacetylation of transcription factors on their activation. One is activated, and another is inactivated on a case by case basis. On the contrary, deacetylated histones cause the downregulation of their target proteins. NAD nicotinamide adenine dinucleotide, Sir2 silent information regulator 2, SIRT sirtuin, SIRT1 silent mating-type information regulation 2 homolog 1