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Detailed molecular mechanisms of collapsed proximal tubule–podocyte communication under diabetic nephropathy. Initial metabolic changes occurred in proximal tubules, where proximal tubular SIRT1 is reduced by high glucose exposure. This leads to the reduction in Nampt and NMN, causing the decline in the decreased SIRT1 in podocytes. Conditional knockout (CKO) mice: SIRT1 CKO, FK866: Nampt-specific inhibitor. STZ streptozotocin, C57BLKS/J Iar-+Leprdb/+Leprdb(db/db) mice
