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Cytotoxicity induced by combination of drug treatment and hyperthermia. GO-HA-iron oxide particulates (A) without or (B) with Dox were cultured with MDA-MB-231 cells and exposed to magnetic fields, and cell viability was measured. Cell viability measurements are normalized to control cultures of cells in the absence of particulates, drugs, and hyperthermia. Paired Student’s t-test was performed to compare hyperthermia treatment to their respective no-heat controls. **p < 0.01.
