. 2019 Jun 4;4(6):9784–9799. doi: 10.1021/acsomega.9b00652

Table 2. Residues That Are Majorly Involved in the Binding of VLB into the Tubulin Heterodimer^a.

subunit	hydrogen bonds	hydrophobic interactions
α-tubulin	Asn329, Lys336	Leu248, Ile332 Thr349, Gly350, Phe351, Val353
β-tubulin	Lys176, Val177	Ser178, Asp179, Tyr210, Pro222

Residues underlined bind via H-bonds with the CT moiety of VLB, whereas those in italic interact with the vindoline moiety of VLB.

Table 2. Residues That Are Majorly Involved in the Binding of VLB into the Tubulin Heterodimera.