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Long-term dox-mediated transgene regulation. Long-term follow-up (5 years) of serum erythropoietin (Epo) level in three macaques (Mac 19, Mac 20, and Mac 21) injected using the locoregional (LR) intravenous route of administration.10 Dox administrations are indicated by dotted lines. The gray area illustrates the physiologic basal levels of Epo (established as the mean ± 2 SD of 182 measures of Epo in serum samples obtained from 32 cynomolgus macaques).
