Table 2.

Candidate Variants of the 277 Known Cancer Susceptibility Genes Identified in the 17 NMTC Families

Family ID	Position (Hg19)	dbSNP ID	Gene	Variant type	Effect	Average Z-scorea
G	chr22:29091856	rs555607708	CHEK2	frameshift	p.Thr367fs	2.792
G	chr10:72360387	rs35947132	PRF1	missense	p.Ala91Val	0.474
N	chr11:108143456	rs1800057	ATM	missense	p.Pro1054Arg	0.456
M	chr11:108143456	rs1800057	ATM	missense	p.Pro1054Arg	0.632
M	chr11:108155132	rs149711770	ATM	missense	p.Ala1309Thr	0.632
H	chr15:86087095	rs74502151	AKAP13	missense	p.Gly191Arg	1.755
O	chr17:78225167	rs140131205	SLC26A11	missense	p.Gly566Arg	0.456

^aValue represents the average Z-score of the two adjacent SNP markers in linkage analysis within each family.