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. 2019 Jul 17;29(7):934–945. doi: 10.1089/thy.2018.0709

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© Julieta Fernandez-Ruocco et al. 2019; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 1. — Characterization of the hypothyroidism animal models. (A) Free thyroxine (T4) blood levels are almost undetectable after two weeks of either primary or central hypothyroidism. (B) Serum thyrotropin (TSH) levels were increased more than 10-fold in primary hypothyroidism but were undetectable in animals with central hypothyroidism. (C) Thyroid gland weight showed opposite changes in primary and central hypothyroidism after six weeks of induction. (D) Hematoxylin and eosin stained sections of the thyroid gland six weeks after induction of primary (pHT) and central hypothyroidism (cHT) also show opposite structural modifications. Scale bars indicate 200 μm and 100 × μm at 20 × and 40 × , respectively. n = 18 control, 15 pHT, and 17 cHT animals. Means ± standard error of the mean (SEM). *p < 0.05; **p < 0.01.